Reply to Hoffmann

Reply from L.G. Harshman and A.A. Hoffmann.

Gernot Hoffmann

Lawrence's book review unfair to Hoffmann

common ancestor lacked a bacterial protein that would be recognizable as a member of the mitochondrial porin protein family, but had a protein translocase that served to import proteins across the outer mitochondrial membrane. We propose that this protein translocase was of bacterial origin, and had an amino-terminal domain with features common to POTRA domains. In the 'endosymbiont model', ATO...

The Authors’ Reply

Hoffmann syndrome: a case report

Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudohypertrophy. We report a 39 year old male with primary hypothyroidism diagnosed at childhood and not on regular thyroxine therapy who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelli...